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It has been amply demonstrated that PGE2 and PGF2α are effective in evoking myometrial contraction whether the uterus is pregnant or not. Since 1971 when Karim and Sharma reported that labor could be induced by oral administration of PGE2, many clinical reports were published with different results. A clinical study was performed to know the clinical reaction of oral PGE2 for induction of labor. Induction of labor was carried out in 50 patients between 36 and 44 weeks of normal gestation. The results were as follows: 1. Induction succeeded in 75% of primigravidas, in 90% of multigravidas and the overall success rate was 84 per cent. 2. Failure rate in the group with pelvic score 0-4 was 36.8% while the same rate was 3.2% in the group with pelvic score 5 or more. 3. The failure rate was 19.5% in the group with intact membrance, while no failure was observed in the group with premature of membranes. 4. Lag period was 93.5 minutes in primigravidas and 61.9 minutes in multigravidas on the average. The mean induction delivery time was 9.3 hours in primigravidas and 6.6 hours in multigravidas. 5. The mean total dosage of oral PGE2 was 4.35mg in primigravidas, 3.42mg in multigravidas, and overall 3.89mg. 6. In only 4 cases, mild and transient nausea appeared, which was spontaneously subsided without specific management. 7. During introduction of labor, no significant changes occurred in blood pressure and pulse rate, and newborn babys` condition were excellent with Apgar score 7 or more.
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